Medik8 Pretox 20 - Injection-Free alternative to Botulinum Toxin treatment
Muscle Relaxant Gel in Liposome Delivery System.

Muscles contract when they receive a neurotransmitter release from a nerve. Like Botulinum Toxin A, Pretox releases the amount of nerve stimulation on the local muscle tissue being targeted but unlike Botulinum Toxin A, Pretox does not paralyse the muscle completely.

Instead it gently and temporarily reduces the strength of specific muscle contractions, thus the formulation of new lines and wrinkles is reduced and old lines appear much less prominent - leaving you with smoother younger looking skin.

Directions
Apply sparingly to targeted areas once in the morning and again in the evening, preferably after cleansing and toning. If using other skin treatment products, allow Pretox to absorb for 5 - 10 minutes
 
Results and Science

• Pretox® contains an inoffensive hexapeptide composed of natural amino acids
• It is a safe and relatively inexpensive alternative to harsh, muscle paralysis treatment
• Stimulates the skin fibroblasts in order to reconstitute the extracellular matrix
• Leads to the synthesis of collagen I and IV, fibronectine and glycosaminoglycans (GAGs
• Stimulates wound healing and gene expression, without the pro-inflammatory reactions of other treatments

Pretox® reduces the depth of the wrinkles in the face caused by the contraction of the muscles of facial expression, especially in the forehead & around the eyes.

It prevents the ageing of skin induced by repeated facial movements caused by excessive catecholamine release.

This graph (left) shows the effect that Pretox has on the release of catecholamine, compared to a related peptide.
 
Clinical tests have shown that Pretox® inhibits the SNARE Complex in ageing skin. The graph below shows tests carried out comparing Pretox 10® with 6 other brands of peptides with regard to the percentage formulation of the SNARE Complex

As is clearly visible, Pretox 10, in a similar way to Botulinum Toxin A, inhibits SNARE complex formation, that is to say muscle contraction to a greater extent than the control and other related peptides.

In fact, Pretox 10 is up to 70% more effective at reducing muscle stimulation than others available.